HTCC: Broad Range Inhibitor of Coronavirus Entry.
Identifieur interne : 001014 ( Main/Exploration ); précédent : 001013; suivant : 001015HTCC: Broad Range Inhibitor of Coronavirus Entry.
Auteurs : Aleksandra Milewska [Pologne] ; Kamil Kaminski [Pologne] ; Justyna Ciejka [Pologne] ; Katarzyna Kosowicz [Pologne] ; Slawomir Zeglen [Pologne] ; Jacek Wojarski [Pologne] ; Maria Nowakowska [Pologne] ; Krzysztof Szczubiałka [Pologne] ; Krzysztof Pyrc [Pologne]Source :
- PloS one [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Chitosane.
- pharmacologie : Antiviraux, Chitosane, Composés d'ammonium quaternaire.
- physiologie : Coronavirus.
- Animaux, Coronavirus, Fusion membranaire, Humains, Lignée cellulaire, Macaca mulatta, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Cell Line, Chitosan (analogs & derivatives), Chitosan (pharmacology), Coronavirus (drug effects), Coronavirus (physiology), Humans, Macaca mulatta, Membrane Fusion (drug effects), Quaternary Ammonium Compounds (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Chitosan.
- chemical , pharmacology : Antiviral Agents, Chitosan, Quaternary Ammonium Compounds.
- drug effects : Coronavirus, Membrane Fusion, Virus Replication.
- physiology : Coronavirus.
- Animals, Cell Line, Humans, Macaca mulatta.
Abstract
To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses.
DOI: 10.1371/journal.pone.0156552
PubMed: 27249425
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses. </div>
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